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Patients with NCGS experience significant relief from their symptoms when following a gluten-free diet. A lifelong gluten-free diet requires a lot of perseverance. There is therefore great interest in exploring alternative possibilities. A review by Calabriso et al. (2022) deals with the protective function of polyphenols and their possible dietary support to counteract negative reactions to gluten.

New research by de Graaf et. al. evaluates Non-Celiac Wheat Sensitivity (NCWS) with a focus on the effect of expectancy versus actual gluten intake on symptoms. The study is among the first to manipulate gluten expectancy and provide a clear picture of the nocebo effect in NCWS.

The objective of a recent study was to evaluate the structural and inflammatory features of NCWS compared to controls and celiac disease with milder enteropathy, since the histological changes induced by gluten in the duodenal mucosa of patients with NCWS is not well defined.

Therapy for Non Celiac Gluten Sensitivity (NCGS) recommends complete elimination of gluten from the diet. A recent study by Scricciolo et al. investigated whether novel enzymes, designed to help metabolize gluten, can support reintroduction of gluten without triggering symptoms.